O15 Venous Leg Ulceration: an assessment of associated lifestyle, sociodemographic and clinical factors using UK Biobank

Abstract Introduction A number of factors have reportedly been associated with venous leg ulceration (VLU) however many these remain disputed. UK Biobank (UKB) is an electronic dataset that provides in-depth detail on the lives its participants. The aim this research to utilise UKB understand VLU. Methods Participants in historical or active were identified and age, sex comorbidity matched control group was formed. multivariate logistic regression used explore VLU significant expressed through odds ratios (OR). Mortality investigated using a Kaplan Meier plot log-rank test. Data analysis preformed R Studio Version 1.2.5033 Python 3.8.10. Results Factors included; male gender, older deprivation (OR 1.27), obesity 1.40), current smoking 1.21), immoderate alcohol intake 1.32), previous deep vein thrombosis 3.07), depression loneliness 1.21). Biochemical included low haemoglobin concentrations 1.50), circulating lymphocyte percentages 1.57), raised glycated (HbA1c) 2.92), c-reactive protein 1.41), cystatin C 1.11) Vitamin D levels 1.52). At median follow up 11.5 years, mortality participants 28%; significantly higher than controls (P < 0.001). Conclusion are comorbid poorer physical, social psychological wellbeing.